Whatever level you may be, wherever you may be - kill everything! You never know when something cool may drop.
A number of quests start from creature drops - sometimes a previous quest will tell you to kill a number of creatures, and they will drop a special item.
In other cases, you may come across named mobs - these may be appear slightly different to the other creatures, wander large areas or be slightly more powerful. Kill them! They may drop a nice uncommon item, or an item that starts a quest. If someone else is camping spawn point of a special creature, and you are a pet class, set your pet on aggressive and it'll get there first :)
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